Publications

発表論文

2024

    • Masui, A., Hashimoto, R., Matsumura, Y., Yamamoto, T., Nagao, M., Noda, T., Takayama, K. and Gotoh S. Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants. Stem Cell Reports 19, 545-561 (2024)
    • Chen, SJ., Hashimoto, K., Fujio, K., Hayashi, K., Paul, S.K., Yuzuriha, A., Qiu, WY., Nakamura, E., Kanashiro, MA., Kabata, M., Nakamura, S., Sugimoto, N., Kaneda, A., Yamamoto, T., Saito, H., Takayama, N. and Eto, K. A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility. Nature Communications 15, 2588 (2024)
    • Sun, L., Jin, Y., Nishio, M., Watanabe, M., Kamakura, T., Nagata, S., Fukuda, M., Maekawa, H., Kawai, S., Yamamoto, T. and Toguchida, J. Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressive Life Science Alliance 7, e202302219 (2024)
    • Tsujimoto, H., Hoshina, A., Mae, S., Araoka, T., Changting, W., Ijiri, Y., Nakajima-Koyama, M., Sakurai, S., Okita, K., Mizuta, K., Niwa, A., Saito, KM., Saitou, M., Yamamoto, T., Graneli, C., Woollard, KJ. and Osafune, K. Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells Cell Reports 43, 113602 (2024)
    • Okubo, T., Rivron, N., Kabata, M., Masaki, H., Kishimoto, K., Semi, K., Nakajima-Koyama, M., Kunitomi, H., Kaswandy, B., Sato, H., Nakauchi, H., Woltjen, K., Saitou, M., Sasaki, E., Yamamoto, T. and Takashima, Y. Hypoblast from human pluripotent stem cells regulates epiblast development Nature 626, 357–366 (2024)

2023

    • Ito, Y., Yamagata, M., Yamamoto, T., Hirasaka, K., Nikawa, T. and Sato, T. The reciprocal regulation between mitochondrial-associated membranes and Notch signaling in skeletal muscle atrophy Elife 12, RP89381 (2023)
    • Kozuki, S., Kabata, M., Sakurai, S., Iwaisako, K., Nishimura, T., Toi, M., Yamamoto, T. and Toyoshima, F. Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice. Commun. Biol. 6, 1226 (2023)
    • Kanatsu-Shinohara, M., Shiromoto, Y., Ogonuki, N., Inoue. K., Hattori. S., Miura, K., Watanabe, N., Hasegawa, A., Mochida, K., Yamamoto, T., Miyakawa, T., Ogura, A. and Shinohara, T. Intracytoplasmic sperm injection induces transgenerational abnormalities in mice J. Clin. Invest. 133, e170140 (2023)
    • Yoshikawa, T., Oguchi, A., Toriu, N., Sato, Y., Kobayashi, T., Ogawa, O., Haga, H., Sakurai, S., Yamamoto, T., Murakawa, Y. and Yanagita, M. Tertiary Lymphoid Tissues Are Microenvironments with Intensive Interactions between Immune Cells and Proinflammatory Parenchymal Cells in Aged Kidneys J. Am. Soc. Nephrol. 34, 1687-1708 (2023)
    • Ikeda, H., Miyao, S., Nagaoka, S., Takashima, T., Law, S., Yamamoto, T. and Kurimoto, K. High-quality single-cell transcriptomics from ovarian histological sections during folliculogenesis Life Science Alliance 6 e202301929 (2023)
    • Kawamura, Y., Oka, K., Semba, T., Takamori, M., Sugiura, Y., Yamasaki, R., Suzuki, Y., Chujo, T., Nagase, M., Oiwa, Y., Fujioka, S., Homma, S., Yamamura, Y., Miyawaki, S., Narita, M., Fukuda, T., Sakai, Y., Ishimoto, T., Tomizawa, K., Suematsu, M., Yamamoto, T., Bono, H., Okano, H. and Miura, K. Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats. EMBO J. e111133 (2023)
    • Sunadome, K., Erickson, AG., Kah, D., Fabry, B., Adori, C., Kameneva, P., Faure, L., Kanatani, S., Kaucka, M., Dehnisch EI. Tesarova,M. Zikmund,T. Kaiser, J., Edwards, S., Maki, K., Adachi, T., Yamamoto, T., Fried, K. and Adameyko, I. Directionality of developing skeletal muscles is set by mechanical forces. Nature Communications 14, 3060 (2023)
    • Iwatsuki, K., Oikawa, M., Kobayashi, H., Penfold, CA., Sanbo, M., Yamamoto, T., Hochi, S., Kurimoto, K., Hirabayashi, M. and Kobayashi, T. Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells Cell Rep Methods 3 100542 (2023)
    • Shinohara, T., Yamamoto, T., Morimoto, H., Shiromoto, Y. and Kanatsu-Shinohara, M. Allogeneic offspring produced by induction of PD-L1 in spermatogonial stem cells via self-renewal stimulation. Stem Cell Reports 18, 985-998 (2023)
    • Hashimoto, R., Tamura, T., Watanabe, Y., Sakamoto, A., Yasuhara, N., Ito, H., Nakano, M., Fuse, H., Ohta, A., Noda, T., Matsumura, Y., Nagao, M., Yamamoto, T., Fukuhara, T. and Takayama K. Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids. Mol. Pharm. 20, 2276-2287 (2023)
    • Gyobu-Motani, S., Yabuta, Y., Mizuta, K., Katou, Y., Okamoto, I., Kawasaki, M., Kitamura, A., Tsukiyama, T., Iwatani, C., Tsuchiya, H., Tsujimura, T., Yamamoto, T., Nakamura, T. and Saitou, M. Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys. EMBO J. e112962 (2023)
    • Deguchi, S., Kosugi, K., Hashimoto, R., Sakamoto, A., Yamamoto, M., Krol, RP., Gee, P., Negoro, R., Noda, T., Yamamoto, T., Torisawa, YS., Nagao, M. and Takayama, K. Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips. PNAS Nexus 2, pgad029 (2023)

  13. Nakajima, H., Ishikawa, H., Yamamoto, T., Chiba, A., Fukui, H., Sako, K., Fukumoto, M., Mattonet, K., Kwon, HB., Hui, SP., Dobreva, GD., Kikuchi, K., Helker, CSM., Stainier, DYR. and Mochizuki N. Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Dev Cell 58, 224–238 (2023)

  14. Yamanaka, Y., Hamidi, S., Yoshioka-Kobayashi, K., Munira, S., Sunadome, K., Zhang, Y., Kurokawa, Y., Ericsson, R., Mieda, A., Thompson, JL., Kerwin, J., Lisgo, L, Yamamoto, T., Moris, N., Martinez-Arias, A., Tsujimura, T. and Alev, C. Reconstituting human somitogenesis in vitro. Nature 614, 509-520 (2023)

2022

  1. Imamura, K., Izumi, Y., Nagai, M., Nishiyama, K., Watanabe, Y., Hanajima, R., Egawa, N., Ayaki, T., Oki, R., Fujita, K., Uozumi, R., Morinaga, A., Hirohashi, T., Fujii, Y.,  Yamamoto, T., Tatebe, H., Tokuda, T., Takahashi, N., Morita, S., Takahashi, R. and Inoue, H. Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial. eClinicalMedicine 53 101707-101707, (2022)

  2. Hashimoto, R., Takahashi, J., Shirakura, K., Funatsu, R., Kosugi, K., Deguchi, S., Yamamoto, M., Tsunoda, Y., Morita, M., Muraoka, K., Tanaka, M., Kanbara, T., Tanaka, S., Tamiya, S., Tokunoh, N., Kawai, A., Ikawa, M., Ono, C., Tachibana, K., Kondoh, M., Obana, M., Matsuura, Y., Ohsumi, A., Noda, T., Yamamoto, T., Yoshioka, Y., Torisawa, YS., Date, H., Fujio, Y., Nagao, M., Takayama, K. and Okada, Y. SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression. Science Adv. 8, eabo6783 (2022)

  3. Imoto, Y., Nakamura, T., Escolar, EG., Yoshiwaki, M., Kojima, Y., Yabuta, Y., Katou, Y., Yamamoto, T., Hiraoka, Y. and Saitou, M. Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis. Life Science Alliance 5 e202201591 (2022)

  4. Ichijo, R., Maki, K., Kabata, M., Murata, T., Nagasaka, A., Ishihara, S., Haga, H., Honda, T., Adachi, T., Yamamoto, T. and Toyoshima, F. Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin. Nature Aging 2, 592-600 (2022)

  5. Nagano, M., Hu, B., Yokobayashi, S., Yamamura, A., Umemura, F., Coradin, M., Ohta, H., Yabuta, Y., Ishikura, Y., Okamoto, I., Ikeda, H., Kawahira, N., Nosaka, Y., Shimizu, S., Kojima, Y., Mizuta, K., Kasahara, T., Imoto, Y., Meehan, K., Stocsits, R., Wutz, G., Hiraoka, Y., Murakawa, Y., Yamamoto, T., Tachibana, K., Peters, JM., Mirny, LA., Garcia, BA., Majewski, J. and Saitou, M. Nucleome programming is required for the foundation of totipotency in mammalian germline development. EMBO J. 41, e110600 (2022)

  6. Sano, E., Suzuki, T., Hashimoto, R., Itoh, Y., Sakamoto, A., Sakai, Y., Saito, A., Okuzaki, D., Motooka, D., Muramoto, Y., Noda, T., Takasaki, T., Sakuragi, JI., Minami, S., Kobayashi, T., Yamamoto, T., Matsumura, Y., Nagao, M., Okamoto, T. and Takayama, K. Cell response analysis in SARS-CoV-2 infected bronchial organoids. Commun. Biol. 5, 516 (2022)

  7. Iwasaki, M., Kawahara, Y., Okubo, C., Yamakawa, T., Nakamura, M., Tabata, T., Nishi, Y., Narita, M., Ohta, A., Saito, H., Yamamoto, T., Nakagawa, M., Yamanaka, S. and Takahashi, K. Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells. iScience 25, 104289 (2022)

  8. Ito, K., Nagata, K., Ohta, S., Matsuda, Y., Ukai, T., Yasuda, I., Ota, A., Kobayashi, R., Kabata, M., Sankoda, N., Maeda, T., Woltjen, K., Yang, L., Maruyama, R., Katayama, R., Yamamoto, T. and Yamada, Y. The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets. Cell Reports 39, 110721 (2022)

  9. Nalbandian, M., Zhao, M., Kato, M., Jonouchi, T., Nakajima-Koyama, M., Yamamoto, T and Sakurai, H. Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation Life Science Alliance 5 e02101312 (2022)

  10. Oikawa, M., Kobayashi, H., Sanbo, M., Mizuno, N., Iwatsuki, K., Takashima, T., Yamauchi, K., Yoshida, F., Yamamoto, T., Shinohara, T., Nakauchi, H., Kurimoto, K., Hirabayashi, M. and Kobayashi, T. Functional primordial germ cell-like cells from pluripotent stem cells in rats. Science 376, 176-179 (2022)

  11. Oka, K., Fujioka, S., Kawamura, Y., Komohara, Y., Chujo, T., Sekiguchi, K., Yamamura, Y., Oiwa, Y., Omamiuda-Ishikawa, N., Komaki, S., Sutoh, Y., Sakurai, S., Tomizawa, K., Bono, H., Shimizu, A., Araki, K., Yamamoto, T., Yamada, Y., Oshiumi, H. and Miura, K. Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked molerats. Commun. Biol. 5, 287 (2022)

  12. Kozuki, S., Sakurai, S., Suzuki, A., Yamamoto, T. and Toyoshima, F. Delineation of biliary epithelial cell dynamics in maternal liver during pregnancy. Genes Cells 27, 192-201 (2022)

  13. Sawada, A., Yamamoto, T. and Sato, T. Tceal5 and Tceal7 Function in C2C12 Myogenic Differentiation via Exosomes in Fetal Bovine Serum. Int. J. Mol. Sci. 23, 2036 (2022)

  14. Hirano, M., So, Y., Tsunekawa, S., Kabata, M., Ohta, S., Sagara, H., Sankoda, N., Taguchi, J., Yamada, Y., Ukai, T., Kato, M., Nakamura, J., Ozawa, M., Yamamoto, T. and Yamada, Y. MYCL-mediated reprogramming expands pancreatic insulin-producing cells. Nature Metabolism 4, 254-268 (2022)

  15. Fujita, Y., Hirosawa, M., Hayashi, K., Hatani, T., Yoshida, Y., Yamamoto, T. and Saito, H. A versatile and robust cell purification system with an RNA-only circuit composed of microRNA-responsive ON and OFF switches. Science Adv. 8, eabj1793 (2022)

  16. Sato, Y., Oguchi, A., Fukushima, Y., Masuda, K., Toriu, N., Taniguchi, K., Yoshikawa, T., Cui, X., Kondo, M., Hosoi, T., Komidori, S., Shimizu, Y., Fujita, H., Jiang, L., Kong, Y., Yamanashi, T., Seita, J., Yamamoto, T., Toyokuni, S., Hamazaki, Y., Hattori, M., Yoshikai, Y., Boor, P., Floege, J., Kawamoto, H., Murakawa, Y., Minato, N. and Yanagita, M. CD153-CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury. J. Clin. Invest. 132, e146071 (2022)

2021

  1. Okamoto, I., Nakamura, T., Sasaki, K., Yabuta, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Ema, M., Yamamoto, T. and Saitou, M. The X-chromosome dosage compensation program during the development of cynomolgus monkeys. Science 374 eabd8887 (2021)

  2. Yokobayashi, S., Yabuta, Y., Nakagawa, M., Okita, K., Hu, B., Murase, Y., Nakamura, T., Bourque, G., Majewski, J., Yamamoto, T. and Saitou, M. Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells. Cell Reports 37 109909 (2021)

  3. Matsumoto, R., Yamamoto, T. and Takahashi, Y. Complex Organ Construction from Human Pluripotent Stem Cells for Biological Research and Disease Modeling with New Emerging Techniques. Int. J. Mol. Sci. 22, 10184 (2021)

  4. Ishikura, Y., Ohta, H., Sato, T., Murase, Y., Yabuta, Y., Kojima, Y., Yamashiro, C., Nakamura, T., Yamamoto, T., Ogawa, T. and Saitou, M. In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells. Cell Stem Cell 28, 2167-2179 (2021)

  5. Taguchi, J., Shibata, H., Kabata, M., Kato, M., Fukuda, K., Tanaka, A., Ohta, S., Ukai, T., Mitsunaga, M., Yamada, Y., Nagaoka, S., Yamazawa, S., Ohnishi, K., Woltjen, K., Ushiku, T., Ozawa, M., Saitou, M., Shinkai, Y., Yamamoto, T. and Yamada, Y. DMRT1-mediated reprogramming 1 drives development of cancer resembling human germ cell tumors with features of totipotency. Nature Communications 12, 5041 (2021)

  6. Jo, N., Zang, R., Ueno, H., Yamamoto, T., Weiskopf, D., Sette, A., Nagao, M., Yamanaka, S. and Hamazaki, Y. Aging and CMV infection affect pre-existing SARS-CoV-2-reactive CD8+ T cells in unexposed individuals. Frontiers in Aging 2, 719342 (2021)

  7. Sasaki, K., Oguchi, A., Cheng, K., Murakawa, Y., Okamoto, I., Ohta, H., Yabuta, Y., Iwatani, C., Tsuchiya, H., Yamamoto, T., Seita, Y. and Saitou, M. The embryonic ontogeny of the gonadal somatic cells in mice and monkeys. Cell Reports 35 109075 (2021)

  8. Sano, E., Deguchi, S., Sakamoto, A., Mimura, N., Hirabayashi, A., Muramoto, Y., Noda, T., Yamamoto, T. and Takayama, K. Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells. iScience 24 102428 (2021)

  9. Io, S., Kabata, M., Iemura, Y., Semi, K., Morone, N., Minagawa, A., Wang, B., Okamoto, I., Nakamura, T., Kojima, Y., Iwatani, C., Tsuchiya, H., Kaswandy, B., Kondoh, E., Kaneko, S., Woltjen, K., Saitou, M., Yamamoto, T., Mandai, M. and Takashima, Y. Capturing Human Trophoblast Development with Naive Pluripotent Stem Cells In Vitro. Cell Stem Cell 28 1023-1039 (2021)

  10. Yuzuriha, A., Nakamura, S., Sugimoto, N., Kihara, S., Nakagawa, M., Yamamoto, T., Sekiguchi, K. and Eto, K. Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis. Stem Cell Research 53 10228 (2021)

  11. Kojima, Y., Yamashiro, C., Murase, Y., Yabuta Y., Okamoto, I., Iwatani, C., Tsuchiya, H., Nakaya, M., Tsukiyama, T., Nakamura, T., Yamamoto, T. and Saitou, M. GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program. Life Science Alliance 4 e202000974 (2021)

  12. Katagiri, N., Hitomi, H., Mae, S., Kotaka, M., Lei, L., Yamamoto, T., Nishiyama, A. and Osafune, K. Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells. Scientific Reports 11 3936 (2021)

  13. Ichijo, R., Kabata, M., Kidoya, H., Muramatsu, F., Ishibashi, R., Abe, K., Tsutsui, K., Kubo, H., Iizuka, Y., Kitano, S., Miyachi, H., Fujiwara, H., Sada, A., Yamamoto, T. and Toyoshima, F. Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs. Science Adv. 7, eabd2575 (2021)

  14. Morimoto, H., Yamamoto T., Miyazaki, T., Ogonuki, N., Ogura, A., Tanaka, T., Kanatsu-Shinohara, M., Yabe-Nishimura, C., Zhang, H., Pommier, Y., Trumpp, A. and Shinohara, T. An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia Genes Dev. 35, 250-260 (2021)

  15. Sankoda, N., Tanabe, W., Tanaka, A., Shibata, H., Woltjen, K., Chiba, T., Haga, H., Sakai, Y., Mandai, M., Yamamoto, T., Yamada, Y., Uemoto, S. and Kawaguchi, Y. Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice. Nature Communications 12, 560 (2021)

  16. Ohta, H., Yabuta, Y., Kurimoto, K., Nakamura, T., Murase, Y., Yamamoto, T. and Saitou, M. Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro. Biol. Reprod. 104, 344-360 (2021)

2020

  1. Senoo, M., Hozoji, H., Ishikawa-Yamauchi, Y., Takijiri, T., Ohta, S., Ukai, T., Kabata, M., Yamamoto, T., Yamada, Y., Ikawa, M. and Ozawa, M.RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3 J. Reprod. Dev. 66, 459-467 (2020)

  2. Murase, Y., Yabuta, Y., Ohta, H., Yamashiro, C., Nakamura, T., Yamamoto, T. and Saitou, M. Long-term expansion with germline potential of human primordial germ cell-like cells in vitro. EMBO J. 39 e104929 (2020)

  3. Yagi, M., Kabata, M., Tanaka, A., Ukai, T., Ohta, S., Nakabayashi, K., Shimizu, M., Hata, K., Meissner, A., Yamamoto, T. and Yamada, Y. Identification of distinct target loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development. Nature Communications 11, 3199 (2020)

  4. Matsuda, M., Yamanaka, Y., Uemura, M., Osawa, M., Saito, MK., Nagahashi, A., Nishio, M., Guo, L., Ikegawa, S., Sakurai, S., Kihara, S., Maurissen, TL., Nakamura, M., Matsumoto, M., Yoshitomi, H., Ikeya, M., Kawakami, N., Yamamoto, T., Woltjen, K., Ebisuya, M., Toguchida, J.and Alev, C. Recapitulating the Human Segmentation Clock with Pluripotent Stem Cells. Nature 580, 124-129 (2020)

  5. Nagaoka, SI., Nakaki, F., Miyauchi, F., Nosaka, Y., Ohta, H., Yabuta, Y., Kurimoto, K., Hayashi, K., Nakamura, T., Yamamoto, T. and Saitou, M. ZGLP1 is a determinant for the oogenic fate in mice. Science 367, eaaw4115 (2020)

  6. Sakai, Y., Nakamura, T., Okamoto, I., Gyobu-Motani, S., Ohta, H., Yabuta, Y., Tsukiyama, T., Iwatani, C., Tsuchiya, H., Ema, M., Morizane, A., Takahashi, J., Yamamoto, T. and Saitou M. Induction of the Germ-Cell Fate from Pluripotent Stem Cells in Cynomolgus Monkeys. Biol. Reprod. 102, 620-638 (2020)

2019

  1. Arai, HN., Sato, F., Yamamoto, T., Woltjen, K., Kiyonari, H., Yoshimoto, Y., Shukunami, C., Akiyama, H., Kist, R. and Sehara-Fujisawa, A. Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate Cell Reports 29, 603-616 (2019)

  2. Sakakura, M., Ohta, S., Yagi, M., Tanaka, A., Norihide, J., Woltjen, K., Yamamoto, T., and Yamada, Y. Smarcb1 maintains the cellular identity and the chromatin landscapes of mouse embryonic stem cells. Biochem. Biophys. Res. Commun. 519, 705-713 (2019).

  3. Komura, S., Ito, K., Ohta, S., Ukai, T., Kabata, M., Itakura, F., Semi, K., Matsuda, Y., Hashimoto, K., Shibata, H., Sone, M., Jo, N., Sekiguchi, K., Ohno, T., Akiyama, H., Shimizu, K., Woltjen, K., Ozawa, M., Toguchida, J., Yamamoto, T. and Yamada, Y. Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell. Nature Communications 10, 3999 (2019)

  4. Kanatsu-Shinohara, M., Yamamoto, T., Toh, H., Kazuki, Y., Kazuki, K., Imoto, J., Ikeo, K., Oshima, M., Shirahige, K., Iwama, A., Nabeshima, Y., Sasaki, H. and Shinohara, T. Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation. Proc. Natl. Acad. Sci. U. S. A. 116, 16404-16409 (2019)

  5. Sato, T., Higashioka, K., Sakurai, H., Yamamoto, T., Goshima, N., Ueno, M. and Sotozono, C. Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells. Stem Cell Reports 13, 352-365 (2019)

  6. Yagi, M., Kabata, M., Ukai, T., Tanaka, A., Shimada, Y., Sugimoto, M., Araki, K., Okita, K., Woltjen, K., Hochedlinger, K., Yamamoto, T., and Yamada, Y. De novo DNA methylation at imprinted loci during reprogramming into naive and primed pluripotency. Stem Cell Reports 12, 1113-1128 (2019)

  7. Morimoto, H., Kanastu-Shinohara, M., Ogonuki, N., Kamimura, S., Ogura, A., Yabe-Nishimura, C., Mori, Y., Morimoto, T., Watanabe, S., Otsu, K., Yamamoto, T. and Shinohara, T. ROS amplification drives mouse spermatogonial stem cell self-renewal. Life Science Alliance 2, e201900374 (2019)

  8. Terada, Y., Jo, N., Arakawa, Y., Sakakura, M., Yamada, Y., Ukai, T., Kabata, M., Mitsunaga, K., Mineharu, Y., Ohta, S., Nakagawa, M., Miyamoto, S., Yamamoto, T. and Yamada, Y. Human pluripotent stem cell-derived tumor model uncovers the embryonic stem cell signature as a key driver in atypical teratoid/rhabdoid tumor. Cell Reports 26, 2608-2621 (2019)

  9. Matsui, S., Ochiai, M., Yasuda, K., Mae, S., Kotaka, M., Toyoda, T., Yamamoto, T. and Osafune, K. Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line. Stem Cell Research 35, 101400 (2019)

  10. Hirata, K., Kodama, S., Nakano, Y., Minaki-Nakagawa, Y., Aoyama, Y., Sakikubo, M., Goto, T., Yoshida, M., Masui, T., Yamamoto, T., Uemoto, S. and Kawaguchi, Y. Exocrine tissue-driven TFF2 prevents apoptotic cell death of endocrine lineage during pancreas organogenesis. Scientific Reports 9, 1636 (2019)

  11. Kagawa, H., Shimamoto, R., Kim, S-I., Oceguera-Yanez, F., Yamamoto, T., Schroeder, T. and Woltjen, K. OVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates. Stem Cell Reports 12, 319-332 (2019)

2018

  1. Yamashiro, C., Sasaki, K., Yabuta, Y., Kojima, Y., Nakamura, T., Okamoto, I., Yokobayashi, S., Murase, Y., Ishikura, Y., Shirane, K., Sasaki, H., Yamamoto, T. and Saitou, M. Generation of human oogonia from induced pluripotent stem cells in vitro. Science 362, 356-360 (2018)

  2. Seo, H, Chen, SJ., Hashimoto, K., Endo, H., Nishi, Y., Ohta, A., Yamamoto, T., Hotta, A., Sawaguchi, A., Hayashi, H., Koseki, N., Murphy, GJ., Fukuda K., Sugimoto, N. and Eto, K. A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production Blood Advances 2, 2262-2272 (2018)

  3. Ito, Y., Nakamura, S., Sugimoto, N., Shigemori, T., Kato, Y., Ohno, M., Sakuma, S., Ito, K., Kumon, H., Hirose, H., Okamoto, H., Nogawa, M., Iwasaki, M., Shunsuke, Kihara., Fujio, K., Matsumoto, T., Higashi, N., Hashimoto, K., Sawaguchi, A., Harimoto, K., Nakagawa, M., Yamamoto, T., Handa, M., Watanabe, N., Nishi, E., Arai, F., Nishimura, S. and Eto, K. Turbulence activates platelet biogenesis to enable clinical scale ex vivo production. Cell 174, 636-648 (2018)

  4. Sogabe, Y., Seno, H., Yamamoto, T. and Yamada, Y. Unveiling epigenetic regulation in cancer, aging and rejuvenation with in vivo reprogramming technology. Cancer Science 109, 2641-2650 (2018)

  5. Shibata, H., Komura, S., Yamada, Y., Sankoda, N., Tanaka, A., Ukai, T., Kabata, M., Sakurai, S., Kuze, B., Woltjen, K., Haga, H., Ito, Y., Kawaguchi, Y., Yamamoto, T. and Yamada, Y. In vivo reprogramming drives Kras-induced cancer development. Nature Communications 9, 2081 (2018)

  6. Ikeda, T., Hikichi, T., Miura, H., Shibata, H., Mitsunaga, K., Yamada, Y., Woltjen, K., Miyamoto, K., Hiratani, I., Yamada, Y., Hotta, A., Yamamoto, T. Okita, K. and Masui, S. Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs. Nature Communications 9, 1378 (2018)

2017

  1. Honjoh, S., Ihara, A., Kajiwara, Y., Yamamoto, T. and Nishida, E. The Sexual Dimorphism of Dietary Restriction Responsiveness in C. elegans Cell Reports 21, 3646-3652 (2017)

  2. Ikeda, H., Sone, M., Yamanaka, S. and Yamamoto T. Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells. Nature Communications 8, 1616 (2017)

  3. Kojima, Y., Sasaki, K., Yokobayashi, S., Sakai, Y., Nakamura, T., Yabuta, Y., Nakaki, F., Nagaoka, S., Woltjen, K., Hotta, A., Yamamoto, T. and Saitou, M. Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells. Cell Stem Cell 21, 517-532 (2017)

  4. Miyauchi, H., Ohta, H., Nagaoka, S., Nakaki, F., Sasaki, K., Hayashi, K., Yabuta, Y., Nakamura, T., Yamamoto, T. and Saitou, M. Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice. EMBO J. 36, 3100-3119 (2017)

  5. Mitani, T., Yabuta, Y., Ohta, H., Nakamura, T., Yamashiro, C., Yamamoto, T., Saitou, M. and Kurimoto, K. Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1 Nucleic Acids Res. 45, 12152-12169 (2017)

  6. Matsuzono, K., Imamura, K., Murakami, N., Tsukita, K., Yamamoto, T., Izumi, Y., Kaji, R., Ohta, Y., Yamashita, T., Abe, K. and Inoue, H. Antisense Oligonucleotides Reduce RNA Foci in Spinocerebellar Ataxia 36 Patient iPSCs. Mol. Ther. Nucleic Acids 8, 211-219 (2017)

  7. Yagi, M., Kishigami, S., Tanaka, A., Semi, K., Mizutani, E., Wakayama, S., Wakayama, T., Yamamoto, T. and Yamada, Y. Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation. Nature 548, 224-227 (2017)

  8. Kitani-Morii, F., Imamura, K., Kondo, T., Ohara, R., Enami, T., Shibukawa, R., Yamamoto, T., Sekiguchi, K., Toguchida, J., Mizuno, T., Nakagawa, M. and Inoue, H. Analysis of neural crest cells from Charcot-Marie-Tooth disease patients demonstrates disease-relevant molecular signature. Neuroreport 28, 814-821 (2017)

  9. Imajo, M., Kondoh, K., Yamamoto, T., Nakayama, K., Nakajima-Koyama, M. and Nishida, E. Antagonistic interactions between ERK MAP kinase and retinoic acid receptor signaling in colorectal cancer cells. Mol. Cell. Biol. 37, e00012-17 (2017)

  10. Ohta, H., Kurimoto, K., Okamoto, I., Nakamura, T., Yabuta, Y., Miyauchi, H., Yamamoto, T., Okuno, Y., Hagiwara, M., Shirane, K., Sasaki, H. and Saitou, M. In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. EMBO J. 36, 1888-1907 (2017)

  11. Imamura, K., Izumi, Y., Watanabe, A., Tsukita, K., Woltjen, K., Yamamoto, T., Hotta, A., Kondo, T., Kitaoka,S., Ohta, A., Tanaka, A., Watanabe, D., Morita, M., Takuma, H., Tamaoka, A., Kunath, T., Wray, S., Furuya, H., Era, T., Makioka, K., Okamoto, K., Fujisawa, T., Nishitoh, H., Homma, K., Ichijo, H., Julien, J.-P., Obata, N., Hosokawa, M., Akiyama, H., Kaneko, S., Ayaki, T., Ito, H., Kaji, R., Takahashi, R., Yamanaka, S. and Inoue, H. The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. Science Transl. Med.9, eaaf3962 (2017)

  12. Sone, M., Morone, N., Nakamura, T., Tanaka, A., Okita, K., Woltjen, K., Nakagawa, M., Heuser, JE., Yamada, Y., Yamanaka, S. and Yamamoto, T. Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Cell Metabolism 25, 1103-1117 (2017)

  13. Yokobayashi, S., Okita, K., Nakagawa, M., Nakamura, T., Yabuta, Y., Yamamoto, T. and Saitou, M. Clonal Variation of Human Induced Pluripotent Stem Cells for Induction into the Germ Cell Fate. Biol. Reprod. 96, 1154-1166 (2017)

  14. Honda, A., Kawano, Y., Izu, H., Choijookhuu, N., Honsho, K., Nakamura, T., Yabuta, Y., Yamamoto, T., Takashima, Y., Hirose, M., Sankai, T., Hishikawa, Y., Ogura, A. and Saitou, M. Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Naive Conversion. Scientific Reports 7, 45285 (2017)

  15. Murakami, N., Imamura, K., Izumi, Y., Egawa, N., Tsukita, K., Enami, T., Yamamoto, T., Kawarai, T., Kaji, R. and Inoue, H. Proteasome impairment in neural cells derived from HMSN-P patient iPSCs. Mol. Brain 10, 7 (2017)

  16. Ashida, Y., Nakajima-Koyama, M., Hirota, A., Yamamoto, T. and Nishida, E. Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cells. Genes Cells 22, 189-202 (2017)

  17. Hashimoto, K., Yamada, Y., Semi, K., Yagi, M., Tanaka, A., Itakura, F., Aoki, H., Kunisada, T., Woltjen, K., Haga, H., Sakai, Y., Yamamoto, T. and Yamada, Y. Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior. Proc. Natl. Acad. Sci. U. S. A. 114, 758-763 (2017)

  18. Sugiyama, H., Takahashi, K., Yamamoto, T., Iwasaki, M., Narita, M., Nakamura, M., Rand, TA., Nakagawa, M., Watanabe, A. and Yamanaka, S. Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 114, 340-345 (2017)

2016

  1. Ishikura, Y., Yabuta, Y., Ohta, H., Hayashi, K., Nakamura, T., Okamoto, I., Yamamoto, T., Kurimoto, K., Shirane, K., Sasaki, H. and Saitou, M. In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells. Cell Reports 17, 2789-2804 (2016)

  2. Hirano, Y., Ihara, K., Masuda, T., Yamamoto, T., Iwata, I., Takahashi, A., Awata, H., Nakamura, N., Takakura, M., Suzuki, Y., Horiuchi, J., Okuno, H. and Saitoe M. Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies. Nature Communications 7, 13471 (2016)

  3. Sasaki, K., Nakamura, T., Okamoto, I., Yabuta, Y., Iwatani, C., Tsuchiya, H., Seita, Y., Nakamura, S., Shiraki, N., Takakuwa, T., Yamamoto, T. and Saitou, M. The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion. Dev. Cell 39, 169-185 (2016)

  4. Nakamura, T., Okamoto, I., Sasaki, K., Yabuta, Y., Iwatani, C., Tsuchiya, H., Seita, Y., Nakamura, S., Yamamoto, T. and Saitou, M. A developmental coordinate of pluripotency among mice, monkeys, and humans. Nature 537, 57-62 (2016)

  5. Ameku, T., Taura, D., Sone, M., Numata, T., Nakamura, M., Shiota, F., Toyoda, T., Matsui, S., Araoka, T., Yasuno, T., Mae, S., Kobayashi, H., Kondo, N., Kitaoka, F., Amano, N., Arai, S., Ichisaka, T., Matsuura, N., Inoue, S., Yamamoto, T., Takahashi, K., Asaka, I., Yamada, Y., Ubara, Y., Muso, E., Fukatsu, A., Watanabe, A., Sato, Y., Nakahata, T., Mori, Y., Koizumi, A., Nakao, K., Yamanaka, S. and Osafune, K. Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models. Scientific Reports 6, 30013 (2016)

  6. Komura, S., Semi, K., Itakura, F., Shibata, H., Ohno, T., Hotta, A., Woltjen, K., Yamamoto, T., Akiyama, H. and Yamada, Y. An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development. Stem Cell Reports 6, 592-606 (2016)

2015

  1. Nakajima-Koyama, M., Lee, J., Ohta, S., Yamamoto, T. and Nishida, E. Induction of Pluripotency in Astrocytes through a Neural Stem Cell-Like State. J. Biol. Chem. 290, 31173-31188 (2015)

  2. Yamashiro, C., Hirota, T., Kurimoto, K., Nakamura, T., Yabuta, Y., Nagaoka, SI., Ohta, H., Yamamoto, T. and Saitou, M. Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice. Biol. Reprod. 94, 7 (2015)

  3. Lee, J., Nakajima-Koyama, M., Sone, M., Koga, M., Ebisuya, M., Yamamoto, T. and Nishida, E. Secreted Ephrin Receptor A7 Promotes Somatic Cell Reprogramming by Inducing ERK Activity Reduction. Stem Cell Reports 5, 480-489 (2015)

  4. Sasaki, K., Yokobayashi, S., Nakamura, T., Okamoto, I., Yabuta, Y., Kurimoto, K., Ohta, H., Moritoki, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Sekiguchi, K., Sakuma, T., Yamamoto, T., Mori, T., Woltjen, K., Nakagawa, M., Yamamoto, T., Takahashi, K., Yamanaka, S. and Saitou M. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Cell Stem Cell 17, 178-194 (2015)

  5. Kurimoto, K., Yabuta, Y., Hayashi, K., Ohta, H., Kiyonari, H., Mitani, T., Moritoki, Y., Kohri, K., Kimura, H., Yamamoto, T., Katou, Y., Shirahige, K. and Saitou, M. Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells. Cell Stem Cell 16, 517-532 (2015)

  6. Kim, S-I., Oceguera-Yanez, F., Hirohata, R., Linker, S., Okita, K., Yamada, Y., Yamamoto, T., Yamanaka, S. and Woltjen, K. KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports 4, 727-743 (2015)

  7. Matsumoto, Y., Ikeya, M., Hino, K., Horigome, K, Fukuta, M., Watanabe, M., Nagata, S., Yamamoto, T., Otsuka, T. and Toguchida, J. New protocol to optimize iPS cells for genome analysis of fibrodysplasia ossificans progressiva. Stem Cells 33, 1730-1742 (2015)

  8. Nakamura, T., Yabuta, Y., Okamoto, I., Aramaki, S., Yokobayashi, S., Kurimoto, K., Sekiguchi, K., Nakagawa, M., Yamamoto, T. and Saitou, M. SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression. Nucleic Acids Res. 43, e60 (2015)

2014

  1. Fukuta, M., Nakai, Y., Kirino, K., Nakagawa, M., Sekiguchi, K., Nagata, S., Matsumoto, Y., Yamamoto, T., Umeda, K., Heike, T., Okumura, N., Koizumi, N., Sato, T., Nakahata, T., Saito, M., Otsuka, T., Kinoshita, S., Ueno, M., Ikeya, M. and Toguchida, J. Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media. PLoS One 9, e112291 (2014)

  2. Sato, T., Yamamoto, T. and Sehara-Fujisawa, A. miR-195/497 induce postnatal quiescence of skeletal muscle stem cells. Nature Communications 5, 4597 (2014)

  3. Ohnishi, K., Semi, K., Yamamoto, T., Shimizu, M., Tanaka, A., Mitsunaga, K., Okita, K., Osafune, K., Arioka, Y., Maeda, T., Soejima, H., Moriwaki, H., Yamanaka, S., Woltjen, K. and Yamada, Y. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell 156, 663-677 (2014)

2013

  1. Ohta, S., Nishida, E., Yamanaka, S. and Yamamoto, T. Global splicing pattern reversion during somatic cell reprogramming. Cell Reports 5, 357-366 (2013)

  2. Sakai, H., Sato, T., Sakurai, H., Yamamoto, T., Hanaoka, K., Montarras, D. and Sehara-Fujisawa, A. Fetal skeletal muscle progenitors have regenerative capacity after intramuscular engraftment in dystrophin deficient mice. PLoS One8, e63016 (2013)

  3. Tanaka, A., Woltjen, K., Miyake, K., Hotta, A., Ikeya, M., Yamamoto, T., Nishino, T., Shoji, E., Sehara-Fujisawa, A., Manabe, Y., Fujii, N., Hanaoka, K., Era, T., Yamashita, S., Isobe, K., Kimura, E. and Sakurai, H. Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro. PLoS One8, e61540 (2013)

  4. Hikichi, T., Matoba, R., Ikeda, T., Watanabe, A., Yamamoto, T., Yoshitake, S., Tamura-Nakano, M., Kimura, T., Kamon, M., Shimura, M., Kawakami, K., Okuda, A., Okochi, H., Inoue, T., Suzuki, A. and Masui, S. Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles. Proc. Natl. Acad. Sci. U. S. A. 110, 6412-6417 (2013)

  5. Nasu, A., Ikeya, M., Yamamoto, T., Watanabe, A., Jin, Y., Matsumoto, Y., Hayakawa, K., Amano, N., Sato, S., Osafune, K., Aoyama, T., Nakamura, T., Kato, T. and Toguchida, J. Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin. PLoS One8, e53771 (2013)

  6. Hirata, A., Utikal, J., Yamashita, S., Aoki, H., Watanabe, A., Yamamoto, T., Okano, H., Bardeesy, N., Kunisada, T., Ushijima, T., Hara, A., Jaenisch, R., Hochedlinger, K. and Yamada Y. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development 140, 66-75 (2013)

  7. Uno, M., Honjoh, S., Matsuda, M., Hoshikawa, H., Kishimoto, S., Yamamoto, T., Ebisuya, M., Yamamoto, T., Matsumoto, K. and Nishida, E. A fasting-responsive signaling pathway that extends life span in C. elegans. Cell Reports 3, 79-91 (2013)

2012

  1. Minami, I., Yamada, K., Otsuji, T.G., Yamamoto, T., Shen, Y., Otsuka, S., Kadota, S., Morone N., Barve, M., Asai, Y., Tenkova-Heuser, T., Heuser, E.J., Uesugi, M., Aiba, A. and Nakatsuji, N. A novel small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Reports 2, 1-13 (2012)

  2. Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., Asaka, I., Aoi, T., Watanabe, A., Yamada, Y., Morizane, A., Takahashi, J., Ayaki, T., Ito, H., Yoshikawa, K., Yamawaki, S., Suzuki, S., Watanabe, D., Hioki, H., Kaneko, T., Makioka, K., Okamoto, K., Takuma, H., Tamaoka, A., Hasegawa, K., Nonaka, T., Hasegawa, M., Kawata, A., Yoshida, M., Nakahata, T., Takahashi, R., Marchetto, M.C., Gage, F.H., Yamanaka, S. and Inoue H. Drug screening for ALS using patient-specific induced pluripotent stem cells. Science Transl. Med.4, 145ra104 (2012)

  3. Tanaka, T., Takahashi, K., Yamane, M., Tomida, S., Nakamura, S., Oshima, K., Niwa, A., Nishikomori, R., Kambe, N., Hara, H., Mitsuyama, M., Morone, N., Heuser, E.J., Yamamoto, T., Watanabe, A., Sato-Otsubo, A., Ogawa, S., Asaka, I., Heike, T., Yamanaka, S., Nakahata, T. and Saito, M. K. Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery. Blood 120, 1299-1308 (2012)

  4. Matsumura, S., Hamasaki, M., Yamamoto, T., Ebisuya, M., Sato, M., Nishida, E. and Toyoshima, F. ABL1 regulates spindle orientation in adherent cells and mammalian skin. Nature Communications 3, 626 (2012)

2011

  1. Sunadome, K., Yamamoto, T., Ebisuya, M., Kondoh, K., Sehara-Fujisawa, A. and Nishida, E. ERK5 regulates muscle cell fusion through Klf transcription factors. Dev. Cell 20, 192-205 (2011)

  2. Endo, T., Kusakabe, M., Sunadome, K., Yamamoto, T. and, Nishida E. The kinase SGK1 in the endoderm and mesoderm promotes ectodermal survival by down-regulating components of the death-inducing signaling complex. Science Signal 4, ra2 (2011)

2010

  1. Mitsushima, M., Aoki, K., Ebisuya, M., Matsumura, S., Yamamoto, T., Matsuda, M., Toyoshima, F. and Nishida, E. Revolving movement of a dynamic cluster of actin filaments during mitosis. J. Cell Biol 191, 453-462 (2010)

  2. Akashi, M., Soma, H., Yamamoto, T., Tsugitomi, A., Yamashita, S., Yamamoto, T., Nishida, E., Yasuda, A., Liao, JK. and Node, K. Noninvasive method for assessing the human circadian clock using hair follicle cells. Proc. Natl. Acad. Sci 107, 15643-15648 (2010)

~2009

  1. Honjoh, S., Yamamoto, T., Uno, M. and Nishida, E. Signalling through Rheb mediates intermittent fasting-induced longevity in C. elegans. Nature 457, 726-730 (2009)

  2. Ebisuya, M., Yamamoto, T., Nakajima, M. and Nishida, E. Ripples from neighbouring transcription. Nature Cell Biol. 10, 1106-1113 (2008)

  3. Maekawa M, Yamamoto T, Kohno M, Takeichi M. and Nishida E. Requirement for ERK MAP kinase in mouse preimplantation development. Development 134:2751-2759 (2007)

  4. Yamamoto, T., Ebisuya, M., Ashida, F., Okamoto, K., Yonehara, S. and Nishida, E. Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression. Curr. Biol. 16:1171-1182 (2006)

  5. Torii, S., Yamamoto, T., Tsuchiya, Y. and Nishida E. ERK MAP kinase in G1 cell cycle progression and cancer. Cancer Science 97:697-702 (2006)

  6. Maekawa, M., Yamamoto, T., Tanoue, T., Yuasa, Y., Chisaka, O. and Nishida E. Requirement of the MAP kinase signaling pathways for mouse preimplantation development. Development 132:1773-1783 (2005)

  7. Torii, S., Nakayama, K., Yamamoto, T. and Nishida E. Regulatory mechanisms and function of ERK MAP kinases. J Biochem. 136:557-561 (2004)

  8. Torii, S., Kusakabe, M., Yamamoto, T., Maekawa, M. and Nishida, E. Sef is a spatial regulator for Ras/MAP kinase signaling. Dev. Cell 7:33-44 (2004)

  9. Maekawa, M., Yamamoto, T. and Nishida, E. Regulation of subcellular localization of the antiproliferative protein Tob by its nuclear export signal and bipartite nuclear localization signal sequences. Exp. Cell Res. 295:59-65 (2004)

  10. Tanoue, T., Yamamoto, T. and Nishida E. Modular structure of a docking surface on MAPK phosphatases. J. Biol. Chem. 277:22942-22949 (2002).

  11. Tanoue, T., Yamamoto, T., Maeda, R. and Nishida, E. A novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38alpha and beta MAPKs. J. Biol. Chem.276:26629-26639 (2001)